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You probably noticed that some important people got left out of the previous section: the companies that build the game consoles themselves What role do Sony, Nintendo, and Microsoft play in the game business Well, to begin with, it s important to realize that the hardware itself is not really the way they make their money Sony sells the PlayStation 2 to the retailers for just a little more than what it costs them to build it in the first place That s because the real profit isn t in the machines, but in the games Each customer only needs one PlayStation, after all What Sony is hoping is that those customers will each buy dozens of games for it Console manufacturers make their money by charging the publishers a fee for each copy of every game published for their machine You re not allowed to publish a game for the Nintendo GameCube, for example, unless you sign a contract with Nintendo authorizing you to do so, and specifying how much you ll pay them for every copy that is manufacured In order to make sure they make a profit whether or not the players buy the game the console manufacturers retain the exclusive right to manufacture the games themselves Only the console manufacturer can press the special CDs or DVDs required, and they charge the publisher about $9 or $10 per copy (If the publisher agrees to make games for only that machine, they can negotiate a better deal) Console manufacturers are also publishers in their own right, doing deals with external developers and maintaining internal development teams They have their own lines of games, often with highly recognizable characters like Mario and Sonic the Hedgehog These help them establish a brand identity and make sure there are games available for the console as soon as it comes out Console manufacturers are the most powerful companies in the business, but they re also the ones taking the biggest risks It costs hundreds of millions of dollars to design and bring a new console machine to market, and experience shows that there s really only room for about three of them at any one time: two main competitors and an also-ran Once it was the Sega Genesis and Super Nintendo, with the Neo-Geo in third place Then it was the Sony PlayStation and Nintendo 64, with the Sega Saturn in third place Now it seems to be the Sony PlayStation 2 and Microsoft Xbox, with the Nintendo GameCube bringing up the rear (After the failure of the Dreamcast, Sega abandoned hardware manufacturing altogether and decided to.

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Chronic disease Empty sella syndrome Sheehan syndrome How is amenorrhea due to hypothalamicpituitary dysfunction diagnosed A history of any of the above conditions suggests this etiology However, low serum levels of FSH and LH are diagnostic Prolactin is usually normal, except in a prolactinoma Gonadal dysgenesis: Turner syndrome Mosaicism 17-hydroxylase deficiency Gonadal agenesis What are the common causes of ovarian dysfunction that lead to secondary amenorrhea Pregnancy Menopause Autoimmune ovarian failure (Blizzard syndrome) Premature ovarian failure Alkylating chemotherapy How is amenorrhea due to ovarian dysfunction diagnosed How can estrogen deficiency due to hypothalamic-pituitary failure be differentiated from that due to ovarian failure What genital outflow obstructions lead to primary amenorrhea What genital outflow obstructions lead to secondary amenorrhea What laboratory tests are indicated in the evaluation of a patient with secondary amenorrhea As the ovaries fail, serum FSH level rises Estrogen deficiency secondary to hypothalamic-pituitary failure usually does not cause hot flashes Ovarian failure may cause hot flashes M llerian anomalies (eg, imperforate hymen) M llerian agenesis Asherman syndrome -hCG TSH Prolactin FSH Progesterone challenge test What diagnoses are suggested by the following lab results: -hCG TSH Pregnancy Hypothyroidism

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Hyperprolactinemia from a pituitary tumor, idiopathic, or due to medications (eg, dopamine antagonists) Postmenopausal state or ovarian failure Hypothalamic disorder or pituitary dysfunction Key: In general, if the gonadotropins are high, the problem is at the level of the ovary If the gonadotropins are low, the problem is in the hypothalamus or pituitary

stick to publishing) Before people buy a console, they want to be sure that there will be a lot of games for it If the publishers spread their efforts over six or seven different machines, there wouldn t be enough games on any one of them for the machine to really take hold

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